DR ORAL 3 - THE EFFICACY OF 12 WEEKS COSMOS CAUDATUS SUPPLEMENTATION ON NEURODEGENERATIVE PREVENTION AMONG OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT : A DOUBLE-BLIND PLACEBO CONTROLLED TRIAL Yee Xing You

Yee Xing You 1, Nor Fadilah Rajab 2 , Hasnah Haron 3 , Hanis Mastura Yahya 3 , Mazlyfarina Mohamad 4 , Normah Che Din 5 , Mohamad Yusof Maskat 6 and Suzana Shahar 1,*

  

1 Dietetics Programme and Centre for Healthy Aging and Wellness (H-Care), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; yeexing@gmail.com

2 Biomedical Science Programme and Centre for Healthy Aging and Wellness (H-Care), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; nfadilah@ukm.edu.my

3 Nutritional Sciences Programme and Centre for Healthy Aging and Wellness (H-Care), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; hasnaharon@ukm.edu.my, hanis.yahya@ukm.edu.my

4 Diagnostic Imaging and Radiotherapy Programme and Centre for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; mazlyfarina@ukm.edu.my

5 Health Psychology Programme, Centre of Rehabilitation and Special Needs, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia Kuala Lumpur, Malaysia; normahcd@ukm.edu.my

6 Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia; yusofm@ukm.edu.my

 

*Correspondence:

Universiti Kebangsaan Malaysia

 

Objective

The prevalence of mild cognitive impairment (MCI) among older adults in Malaysia was 16% and prevention is crucial and timely. Ulam or traditional Malaysian vegetables was commonly consumed by Malaysian population and it has been reported to be rich in polyphenols and antioxidants which might have potential to prevent neurodegenerative diseases. This study aimed to investigate the efficacy of Cosmos caudatus supplement on neurodegenerative prevention among older adults with MCI.

 

Methodology

This is a double-blind, placebo-controlled clinical trial among 48 subjects conducted for 12 weeks in Klang Valley, Malaysia. The sampling method was convenient sampling and we screened the eligibility of subjects based on Peterson (2014) MCI criteria. We used validated tools to access cognitive function and brain activation such as neuropsychological batteries and functional magnetic resonance imaging. Elisa kits were used to analyse oxidative stress biomarkers at baseline and post intervention.

 

Results & Discussion

Two-way mixed ANOVA analysis showed significant improvements in MMSE scores (partial η2=0.150, p=0.049), serum malondialdehyde (MDA) concentration (partial η2=0.097, p=0.047) and brain activation while performing 1-back task (partial η2=0.396, p=0.016) were observed in supplement group. Furthermore, there was significant improvement in percentage mean change of Digit Span in supplement group as compared to placebo group (p<0.05). Quercetin that presents in Cosmos caudatus could pass across blood-brain barrier and it might exert antioxidant properties and biochemical impacts with regards to many oxidative stress-induced ailments for the elderly. It eventually offers protection against degeneration and neural injuries in older adults with MCI.
 

Conclusion

12 weeks of Cosmos caudatus supplementation has the potential to improve global cognitive function and brain activation, reduce oxidative stress among older adults with MCI. The scientific evidence from this study will trigger health promotion of ulam consumption that lead to healthy lifestyle and improve quality of life of older adults with MCI.